|Other Names||Delta-sarcoglycan, Delta-SG, 35 kDa dystrophin-associated glycoprotein, 35DAG, SGCD|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.|
|Cellular Location||Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasm, cytoskeleton|
|Tissue Location||Most strongly expressed in skeletal and cardiac muscle. Also detected in smooth muscle. Weak expression in brain and lung|
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The protein encoded by this gene is one of the four knowncomponents of the sarcoglycan complex, which is a subcomplex of thedystrophin-glycoprotein complex (DGC). DGC forms a link between theF-actin cytoskeleton and the extracellular matrix. This protein isexpressed most abundantly in skeletal and cardiac muscle. Mutationsin this gene have been associated with autosomal recessivelimb-girdle muscular dystrophy and dilated cardiomyopathy.Alternatively spliced transcript variants encoding distinctisoforms have been observed for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Zimmerman, R.S., et al. Genet. Med. 12(5):268-278(2010)Ordonez-Razo, R.M., et al. Genet Test Mol Biomarkers 14(2):237-240(2010)Lin, W.Y., et al. BMC Res Notes 3, 26 (2010) :
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