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ACTR1A Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P61163 |
|---|---|
| Clone Names | 100525300 |
| Gene ID | 10121 |
|---|---|
| Other Names | Alpha-centractin, Centractin, ARP1, Actin-RPV, Centrosome-associated actin homolog, ACTR1A, CTRN1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ACTR1A (HGNC:167) |
|---|---|
| Synonyms | CTRN1 |
| Function | Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P85515}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cell cortex |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a 42.6 kD subunit of dynactin, amacromolecular complex consisting of 10-11 subunits ranging in sizefrom 22 to 150 kD. Dynactin binds to both microtubules andcytoplasmic dynein. It is involved in a diverse array of cellularfunctions, including ER-to-Golgi transport, the centripetalmovement of lysosomes and endosomes, spindle formation, chromosomemovement, nuclear positioning, and axonogenesis. This subunit ispresent in 8-13 copies per dynactin molecule, and is the mostabundant molecule in the dynactin complex. It is an actin-relatedprotein, and is approximately 60% identical at the amino acid levelto conventional actin.
References
Sugarbaker, D.J., et al. Proc. Natl. Acad. Sci. U.S.A. 105(9):3521-3526(2008)Petretti, C., et al. EMBO Rep. 7(4):418-424(2006)Casenghi, M., et al. Dev. Cell 5(1):113-125(2003)Carew, J.A., et al. J. Thromb. Haemost. 1(6):1220-1227(2003)Takahashi, M., et al. Mol. Biol. Cell 13(9):3235-3245(2002)
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