|Other Names||Alpha-centractin, Centractin, ARP1, Actin-RPV, Centrosome-associated actin homolog, ACTR1A, CTRN1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.|
|Cellular Location||Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome|
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This gene encodes a 42.6 kD subunit of dynactin, amacromolecular complex consisting of 10-11 subunits ranging in sizefrom 22 to 150 kD. Dynactin binds to both microtubules andcytoplasmic dynein. It is involved in a diverse array of cellularfunctions, including ER-to-Golgi transport, the centripetalmovement of lysosomes and endosomes, spindle formation, chromosomemovement, nuclear positioning, and axonogenesis. This subunit ispresent in 8-13 copies per dynactin molecule, and is the mostabundant molecule in the dynactin complex. It is an actin-relatedprotein, and is approximately 60% identical at the amino acid levelto conventional actin.
Sugarbaker, D.J., et al. Proc. Natl. Acad. Sci. U.S.A. 105(9):3521-3526(2008)Petretti, C., et al. EMBO Rep. 7(4):418-424(2006)Casenghi, M., et al. Dev. Cell 5(1):113-125(2003)Carew, J.A., et al. J. Thromb. Haemost. 1(6):1220-1227(2003)Takahashi, M., et al. Mol. Biol. Cell 13(9):3235-3245(2002)
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