|Other Names||Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical], Diadenosine 5', 5'''-P1, P4-tetraphosphate asymmetrical hydrolase, Ap4A hydrolase, Ap4Aase, Diadenosine tetraphosphatase, Nucleoside diphosphate-linked moiety X motif 2, Nudix motif 2, NUDT2, APAH1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis.|
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This gene encodes a member of the MutT family ofnucleotide pyrophosphatases, a subset of the larger NUDIX hydrolasefamily. The gene product possesses a modification of the MutTsequence motif found in certain nucleotide pyrophosphatases. Theenzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and isresponsible for maintaining the intracellular level of thedinucleotide Ap4A, the function of which has yet to be established.This gene may be a candidate tumor suppressor gene. Alternativesplicing has been observed at this locus and three transcriptvariants, all encoding the same protein, have been identified.
Vasilenko, N., et al. Virol. J. 7, 31 (2010) :Swarbrick, J.D., et al. J. Biol. Chem. 280(9):8471-8481(2005)Swarbrick, J.D., et al. J. Biomol. NMR 31(2):181-182(2005)Pitcher, W.H. III, et al. Antiviral Res. 58(3):227-233(2003)Guranowski, A., et al. Acta Biochim. Pol. 50(1):123-130(2003)
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