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PHC2 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8IXK0
Clone Names 100528205
Peptide ID 100528205
Additional Information
Gene ID 1912
Other Names Polyhomeotic-like protein 2, hPH2, Early development regulatory protein 2, PHC2, EDR2, PH2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PHC2
Synonyms EDR2, PH2
Function Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Cellular Location Nucleus.
Research Areas
Citations (0)

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In Drosophila melanogaster, the 'Polycomb' group (PcG) ofgenes are part of a cellular memory system that is responsible forthe stable inheritance of gene activity. PcG proteins form a largemultimeric, chromatin-associated protein complex. The proteinencoded by this gene has homology to the Drosophila PcG protein'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 andcolocalize with BMI1 in interphase nuclei of human cells. Thespecific function in human cells has not yet been determined. Twotranscript variants encoding different isoforms have been found forthis gene.


Wu, H., et al. Biochem. Biophys. Res. Commun. 397(3):391-396(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Wang, H., et al. Nature 431(7010):873-878(2004)Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)

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$ 80.00
Cat# BP16122c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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