|Other Names||TATA box-binding protein-associated factor RNA polymerase I subunit A, RNA polymerase I-specific TBP-associated factor 48 kDa, TAFI48, TATA box-binding protein-associated factor 1A, TBP-associated factor 1A, Transcription factor SL1, Transcription initiation factor SL1/TIF-IB subunit A, TAF1A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre- initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.|
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Provided below are standard protocols that you may find useful for product applications.
Initiation of transcription by RNA polymerase I requiresthe formation of a complex composed of the TATA-binding protein(TBP) and three TBP-associated factors (TAFs) specific for RNApolymerase I. This complex, known as SL1, binds to the corepromoter of ribosomal RNA genes to position the polymerase properlyand acts as a channel for regulatory signals. This gene encodes thesmallest SL1-specific TAF. Two transcripts encoding differentisoforms have been identified.
Greco-Stewart, V.S., et al. Virology 386(1):12-15(2009)Yamamoto, K., et al. Mol. Cell. Biol. 24(14):6338-6349(2004)Dynes, J.L., et al. J. Biochem. 135(3):429-438(2004)Hirschler-Laszkiewicz, I., et al. J. Biol. Chem. 278(21):18953-18959(2003)Yuan, X., et al. EMBO Rep. 3(11):1082-1087(2002)
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