|Other Names||DNA topoisomerase 2-alpha, DNA topoisomerase II, alpha isozyme, TOP2A, TOP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity).|
|Cellular Location||Cytoplasm. Nucleus, nucleoplasm. Note=Generally located in the nucleoplasm|
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This gene encodes a DNA topoisomerase, an enzyme thatcontrols and alters the topologic states of DNA duringtranscription. This nuclear enzyme is involved in processes such aschromosome condensation, chromatid separation, and the relief oftorsional stress that occurs during DNA transcription andreplication. It catalyzes the transient breaking and rejoining oftwo strands of duplex DNA which allows the strands to pass throughone another, thus altering the topology of DNA. Two forms of thisenzyme exist as likely products of a gene duplication event. Thegene encoding this form, alpha, is localized to chromosome 17 andthe beta gene is localized to chromosome 3. The gene encoding thisenzyme functions as the target for several anticancer agents and avariety of mutations in this gene have been associated with thedevelopment of drug resistance. Reduced activity of this enzyme mayalso play a role in ataxia-telangiectasia.
Vranic, S., et al. Hum. Pathol. 41(11):1617-1623(2010)Chen, H., et al. Am. J. Surg. Pathol. 34(9):1250-1257(2010)Ye, J., et al. Cell 142(2):230-242(2010)Rossi, E., et al. Histopathology 57(1):81-89(2010)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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