|Other Names||60S acidic ribosomal protein P0, 60S ribosomal protein L10E, RPLP0|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ribosomal protein P0 is the functional equivalent of E.coli protein L10.|
|Cellular Location||Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:19188445, PubMed:17289661).|
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Ribosomes, the organelles that catalyze protein synthesis,consist of a small 40S subunit and a large 60S subunit. Togetherthese subunits are composed of 4 RNA species and approximately 80structurally distinct proteins. This gene encodes a ribosomalprotein that is a component of the 60S subunit. The protein, whichis the functional equivalent of the E. coli L10 ribosomal protein,belongs to the L10P family of ribosomal proteins. It is a neutralphosphoprotein with a C-terminal end that is nearly identical tothe C-terminal ends of the acidic ribosomal phosphoproteins P1 andP2. The P0 protein can interact with P1 and P2 to form a pentamericcomplex consisting of P1 and P2 dimers, and a P0 monomer. Theprotein is located in the cytoplasm. Transcript variants derivedfrom alternative splicing exist; they encode the same protein. Asis typical for genes encoding ribosomal proteins, there aremultiple processed pseudogenes of this gene dispersed through thegenome.
Vascotto, C., et al. Mol. Cell. Biol. 29(7):1834-1854(2009)Rinne, T., et al. Hum. Mol. Genet. 17(13):1968-1977(2008)Chang, T.W., et al. Oncogene 27(3):332-338(2008)Rikova, K., et al. Cell 131(6):1190-1203(2007)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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