|Other Names||DnaJ homolog subfamily A member 3, mitochondrial, DnaJ protein Tid-1, hTid-1, Hepatocellular carcinoma-associated antigen 57, Tumorous imaginal discs protein Tid56 homolog, DNAJA3, HCA57, TID1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.|
|Cellular Location||Mitochondrion matrix. Cytoplasm, cytosol. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein Note=Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK|
|Tissue Location||Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes|
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Provided below are standard protocols that you may find useful for product applications.
DNAJA3 belongs to the evolutionarily conserved DNAJ/HSP40family of proteins. For background information on the DNAJ family,see MIM 608375.
Qian, J., et al. Gastroenterology 138(4):1418-1428(2010)Kurzik-Dumke, U., et al. J Transl Med 8, 58 (2010) :Linnoila, J., et al. Neuron 60(4):625-641(2008)Kurzik-Dumke, U., et al. Int. J. Mol. Med. 21(1):19-31(2008)Kurzik-Dumke, U., et al. Cell. Signal. 19(9):1973-1985(2007)
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