TID1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q96EY1 |
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Clone Names | 100318245 |
Gene ID | 9093 |
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Other Names | DnaJ homolog subfamily A member 3, mitochondrial, DnaJ protein Tid-1, hTid-1, Hepatocellular carcinoma-associated antigen 57, Tumorous imaginal discs protein Tid56 homolog, DNAJA3, HCA57, TID1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DNAJA3 |
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Synonyms | HCA57, TID1 |
Function | Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. |
Cellular Location | Mitochondrion matrix. Cytoplasm, cytosol. Postsynaptic cell membrane; Peripheral membrane protein. Note=Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK |
Tissue Location | Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes |
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Provided below are standard protocols that you may find useful for product applications.
Background
DNAJA3 belongs to the evolutionarily conserved DNAJ/HSP40family of proteins. For background information on the DNAJ family,see MIM 608375.
References
Qian, J., et al. Gastroenterology 138(4):1418-1428(2010)Kurzik-Dumke, U., et al. J Transl Med 8, 58 (2010) :Linnoila, J., et al. Neuron 60(4):625-641(2008)Kurzik-Dumke, U., et al. Int. J. Mol. Med. 21(1):19-31(2008)Kurzik-Dumke, U., et al. Cell. Signal. 19(9):1973-1985(2007)
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