|Other Names||E3 ubiquitin-protein ligase listerin, 632-, RING finger protein 160, Zinc finger protein 294, LTN1, C21orf10, C21orf98, KIAA0714, RNF160, ZNF294|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||C21orf10, C21orf98, KIAA0714, RNF160, ZN|
|Function||E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23685075, PubMed:25132172, PubMed:25578875). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity).|
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Like most RING finger proteins, LTN1 functions as an E3ubiquitin ligase (Chu et al., 2009 [PubMed 19196968]).[supplied byOMIM].
Bengtson, M.H., et al. Nature 467(7314):470-473(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Chu, J., et al. Proc. Natl. Acad. Sci. U.S.A. 106(7):2097-2103(2009)
If you have any additional inquiries please email technical services at firstname.lastname@example.org.