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RNF160 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O94822 |
|---|---|
| Clone Names | 100422009 |
| Gene ID | 26046 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase listerin, 632-, RING finger protein 160, Zinc finger protein 294, LTN1, C21orf10, C21orf98, KIAA0714, RNF160, ZNF294 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | LTN1 |
|---|---|
| Synonyms | C21orf10, C21orf98, KIAA0714, RNF160, ZN |
| Function | E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23685075, PubMed:25132172, PubMed:25578875, PubMed:28757607). Within the RQC complex, LTN1 is recruited to stalled 60S ribosomal subunits by NEMF and mediates ubiquitination of stalled nascent chains (PubMed:25578875). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity). |
| Cellular Location | Cytoplasm, cytosol. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Like most RING finger proteins, LTN1 functions as an E3ubiquitin ligase (Chu et al., 2009 [PubMed 19196968]).[supplied byOMIM].
References
Bengtson, M.H., et al. Nature 467(7314):470-473(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Chu, J., et al. Proc. Natl. Acad. Sci. U.S.A. 106(7):2097-2103(2009)
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