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EPN1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y6I3 |
|---|---|
| Clone Names | 100318169 |
| Gene ID | 29924 |
|---|---|
| Other Names | Epsin-1, EH domain-binding mitotic phosphoprotein, EPS-15-interacting protein 1, EPN1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | EPN1 |
|---|---|
| Function | Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10557078, PubMed:10393179). |
| Cellular Location | Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Membrane, clathrin-coated pit Note=Associated with the cytoplasmic membrane at sites where clathrin- coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
EPN1 is an endocytic accessory protein that interacts withEPS15 (MIM 600051), the alpha subunit of the clathrin adaptor AP2(AP2A1; MIM 601026), and clathrin (see MIM 118960), as well as withother accessory proteins for the endocytosis of clathrin-coatedvesicles.
References
Liu, Z., et al. J. Cell Biol. 186(4):473-480(2009)Kazazic, M., et al. Traffic 10(2):235-245(2009)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Schmid, E.M., et al. PLoS Biol. 4 (9), E262 (2006) :
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