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SIGLEC5 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O15389
Clone Names 2101707
Peptide ID 2101707
Additional Information
Gene ID 8778
Other Names Sialic acid-binding Ig-like lectin 5, Siglec-5, CD33 antigen-like 2, Obesity-binding protein 2, OB-BP2, OB-binding protein 2, CD170, SIGLEC5, CD33L2, OBBP2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1623a was selected from the N-term region of human SIGLEC5 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SIGLEC5
Synonyms CD33L2, OBBP2
Function Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation
Research Areas
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Background

SIGLEC5 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. This protein binds equally to alpha2,3-linked and alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. This molecule is expressed by monocytic/myeloid lineage cells. SIGLEC5 is found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. It is expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.

References

Erickson-Miller, C.L., et al., Exp. Hematol. 31(5):382-388 (2003).Patel, N., et al., J. Biol. Chem. 274(32):22729-22738 (1999).Cornish, A.L., et al., Blood 92(6):2123-2132 (1998).Kim, H.S., Cytogenet. Cell Genet. 84 (1-2), 96 (1999).

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$ 80.00
Cat# BP1623a
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