|Other Names||Beta-2-syntrophin, 59 kDa dystrophin-associated protein A1 basic component 2, Syntrophin-3, SNT3, Syntrophin-like, SNTL, SNTB2, D16S2531E, SNT2B2, SNTL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||D16S2531E, SNT2B2, SNTL|
|Function||Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN.|
|Cellular Location||Membrane. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Cell junction. Cytoplasm, cytoskeleton. Note=Membrane-associated In muscle, it is exclusively localized at the neuromuscular junction (By similarity). In insulinoma cell line, it is enriched in secretory granules.|
|Tissue Location||Ubiquitous. Isoform 1 is the predominant isoform. Weak level of isoform 2 is present in all tested tissues, except in liver and heart where it is highly expressed|
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Dystrophin is a large, rod-like cytoskeletal protein foundat the inner surface of muscle fibers. Dystrophin is missing inDuchenne Muscular Dystrophy patients and is present in reducedamounts in Becker Muscular Dystrophy patients. The protein encodedby this gene is a peripheral membrane protein found associated withdystrophin and dystrophin-related proteins. This gene is a memberof the syntrophin gene family, which contains at least two otherstructurally-related genes.
Costantini, J.L., et al. Blood 114(21):4703-4712(2009)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
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