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UGT1A10 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9HAW8 |
|---|---|
| Clone Names | 100311265 |
| Gene ID | 54575 |
|---|---|
| Other Names | UDP-glucuronosyltransferase 1-10, UDPGT 1-10, UGT1*10, UGT1-10, UGT110, UDP-glucuronosyltransferase 1-J, UGT-1J, UGT1J, UDP-glucuronosyltransferase 1A10, UGT1A10, GNT1, UGT1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | UGT1A10 (HGNC:12531) |
|---|---|
| Synonyms | GNT1, UGT1 |
| Function | [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:18004212, PubMed:18052087, PubMed:18674515, PubMed:18719240, PubMed:19545173, PubMed:23288867, PubMed:26220143). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol (PubMed:18719240, PubMed:23288867, PubMed:26220143). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, caderastan and zolarsatan, drugs which can inhibit the effect of angiotensin II (PubMed:18674515). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein |
| Tissue Location | Liver and colon (PubMed:9271343). Isoform 1 and isoform 2 are expressed in colon, esophagus and small intestine; isoform 2 but not isoform 1 is expressed in liver or kidney (PubMed:18004212). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
UGT1A10 is a UDP-glucuronosyltransferase, an enzymeof the glucuronidation pathway that transforms small lipophilicmolecules, such as steroids, bilirubin, hormones, and drugs, intowater-soluble, excretable metabolites. This gene is part of acomplex locus that encodes several UDP-glucuronosyltransferases.The locus includes thirteen unique alternate first exons followedby four common exons. Four of the alternate first exons areconsidered pseudogenes. Each of the remaining nine 5' exons may bespliced to the four common exons, resulting in nine proteins withdifferent N-termini and identical C-termini. Each first exonencodes the substrate binding site, and is regulated by its ownpromoter. The enzyme encoded by this gene has glucuronidaseactivity on mycophenolic acid, coumarins, and quinolines. [providedby RefSeq].
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Mick, E., et al. J Am Acad Child Adolesc Psychiatry 49(9):898-905(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Tang, L., et al. Mol. Pharm. 7(3):664-679(2010)Itaaho, K., et al. Drug Metab. Dispos. 38(4):687-696(2010)
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