|Other Names||UDP-glucuronosyltransferase 1-10, UDPGT 1-10, UGT1*10, UGT1-10, UGT110, UDP-glucuronosyltransferase 1-J, UGT-1J, UGT1J, UDP-glucuronosyltransferase 1A10, UGT1A10, GNT1, UGT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.|
|Cellular Location||Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein|
|Tissue Location||Liver and colon. Isoform 1 and isoform 2 are expressed in colon, esophagus and small intestine; isoform 2 but not isoform 1 is expressed in liver or kidney (PubMed:18004212)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
UGT1A10 is a UDP-glucuronosyltransferase, an enzymeof the glucuronidation pathway that transforms small lipophilicmolecules, such as steroids, bilirubin, hormones, and drugs, intowater-soluble, excretable metabolites. This gene is part of acomplex locus that encodes several UDP-glucuronosyltransferases.The locus includes thirteen unique alternate first exons followedby four common exons. Four of the alternate first exons areconsidered pseudogenes. Each of the remaining nine 5' exons may bespliced to the four common exons, resulting in nine proteins withdifferent N-termini and identical C-termini. Each first exonencodes the substrate binding site, and is regulated by its ownpromoter. The enzyme encoded by this gene has glucuronidaseactivity on mycophenolic acid, coumarins, and quinolines. [providedby RefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Mick, E., et al. J Am Acad Child Adolesc Psychiatry 49(9):898-905(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Tang, L., et al. Mol. Pharm. 7(3):664-679(2010)Itaaho, K., et al. Drug Metab. Dispos. 38(4):687-696(2010)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.