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VSX1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NZR4 |
|---|---|
| Clone Names | 100318257 |
| Gene ID | 30813 |
|---|---|
| Other Names | Visual system homeobox 1, Homeodomain protein RINX, Retinal inner nuclear layer homeobox protein, Transcription factor VSX1, VSX1, RINX |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | VSX1 |
|---|---|
| Synonyms | RINX |
| Function | Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster (PubMed:10903837). May regulate the activity of the LCR and the cone opsin genes at earlier stages of development (PubMed:10903837). Dispensable in early retinal development (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q91V10}. |
| Tissue Location | In the adult eye, expressed in lens, iris, ciliary body, choroid, optical nerve head and, most strongly, in retina, but not expressed in sclera and cornea. According to PubMed:11978762, expressed in adult retina but not in lens and cornea. Within adult retina, found exclusively in the inner nuclear layer. Isoform 1, isoform 2, isoform 3 and isoform 4 expressed in adult retina, but not in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. Not expressed in thymus and spleen. Expressed in embryonic craniofacial tissue. Expressed in fetal (week 14) retina. Strongly expressed in neonatal retina, weakly in neonatal lens, choroid and cornea (day 1, 4; month 9). |
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Provided below are standard protocols that you may find useful for product applications.
Background
VSX1 contains a paired-likehomeodomain and binds to the core of the locus control region ofthe red/green visual pigment gene cluster. The encoded protein mayregulate expression of the cone opsin genes early in development.Mutations in this gene can cause posterior polymorphous cornealdystrophy and keratoconus.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Dash, D.P., et al. Eye (Lond) 24(6):1085-1092(2010)Stabuc-Silih, M., et al. Cornea 29(2):172-176(2010)Stabuc-Silih, M., et al. Acta Dermatovenerol Alp Panonica Adriat 19(2):3-10(2010)Paliwal, P., et al. Mol. Vis. 15, 2475-2479 (2009) :
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