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MOCS2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O96007 |
|---|---|
| Clone Names | 100324024 |
| Gene ID | 4338 |
|---|---|
| Other Names | Molybdopterin synthase catalytic subunit {ECO:0000255|HAMAP-Rule:MF_03052}, 28112 {ECO:0000255|HAMAP-Rule:MF_03052}, MOCO1-B, Molybdenum cofactor synthesis protein 2 large subunit {ECO:0000255|HAMAP-Rule:MF_03052}, Molybdenum cofactor synthesis protein 2B {ECO:0000255|HAMAP-Rule:MF_03052}, MOCS2B {ECO:0000255|HAMAP-Rule:MF_03052}, Molybdopterin-synthase large subunit, MPT synthase large subunit, MOCS2 {ECO:0000255|HAMAP-Rule:MF_03052}, MCBPE, MOCO1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MOCS2 {ECO:0000255|HAMAP-Rule:MF_03052} |
|---|---|
| Synonyms | MCBPE, MOCO1 |
| Function | Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. |
| Cellular Location | Cytoplasm, cytosol {ECO:0000255|HAMAP- Rule:MF_03052, ECO:0000269|PubMed:15073332} |
| Tissue Location | Highest levels are found in heart and skeletal muscle. Lower levels are present in brain, kidney and pancreas. Very low levels are found in lung and peripheral blood leukocytes |
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Provided below are standard protocols that you may find useful for product applications.
Background
Eukaryotic molybdoenzymes use a unique molybdenum cofactor(MoCo) consisting of a pterin, termed molybdopterin, and thecatalytically active metal molybdenum. MoCo is synthesized fromprecursor Z by the heterodimeric enzyme molybdopterin synthase. Thelarge and small subunits of molybdopterin synthase are both encodedfrom this gene by overlapping open reading frames. The proteinswere initially thought to be encoded from a bicistronic transcript.They are now thought to be encoded from monocistronic transcripts.Alternatively spliced transcripts have been found for this locusthat encode the large and small subunits.
References
Per, H., et al. Brain Dev. 29(6):365-368(2007)Hahnewald, R., et al. Mol. Genet. Metab. 89(3):210-213(2006)Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)Leimkuhler, S., et al. Hum. Genet. 117(6):565-570(2005)Matthies, A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(16):5946-5951(2004)
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