|Other Names||Solute carrier family 2, facilitated glucose transporter member 4, Glucose transporter type 4, insulin-responsive, GLUT-4, SLC2A4, GLUT4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Insulin-regulated facilitative glucose transporter.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration|
|Tissue Location||Skeletal and cardiac muscles; brown and white fat|
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Provided below are standard protocols that you may find useful for product applications.
SLC2A4 is a member of the solute carrier family 2(facilitated glucose transporter) family and encodes a protein thatfunctions as an insulin-regulated facilitative glucose transporter.In the absence of insulin, this integral membrane protein issequestered within the cells of muscle and adipose tissue. Withinminutes of insulin stimulation, the protein moves to the cellsurface and begins to transport glucose across the cell membrane.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Lauritzen, H.P., et al. Am. J. Physiol. Endocrinol. Metab. 299 (2), E169-E179 (2010) :Bogan, J.S., et al. Curr. Opin. Cell Biol. 22(4):506-512(2010)Kohan, K., et al. Reproduction 140(1):123-131(2010)Nair, A.K., et al. PLoS ONE 5 (7), E11444 (2010) :
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