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ELOVL4 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9GZR5 |
|---|---|
| Clone Names | 100517037 |
| Gene ID | 6785 |
|---|---|
| Other Names | Elongation of very long chain fatty acids protein 4, 3-keto acyl-CoA synthase ELOVL4, ELOVL fatty acid elongase 4, ELOVL FA elongase 4, Very-long-chain 3-oxoacyl-CoA synthase 4, ELOVL4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ELOVL4 {ECO:0000255|HAMAP-Rule:MF_03204} |
|---|---|
| Function | Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development. |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03204, ECO:0000269|PubMed:16036915, ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03204} |
| Tissue Location | Expressed in the retina and at much lower level in the brain. Ubiquitous, highest expression in thymus, followed by testis, small intestine, ovary, and prostate. Little or no expression in heart, lung, liver, or leukocates. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ELOVL4 is a membrane-bound protein which is amember of the ELO family, proteins which participate in thebiosynthesis of fatty acids. Consistent with the expression of theencoded protein in photoreceptor cells of the retina, mutations andsmall deletions in this gene are associated with Stargardt-likemacular dystrophy (STGD3) and autosomal dominant Stargardt-likemacular dystrophy (ADMD), also referred to as autosomal dominantatrophic macular degeneration.
References
Kasperaviciute, D., et al. Brain 133 (PT 7), 2136-2147 (2010) :Vasireddy, V., et al. Prog Retin Eye Res 29(3):191-207(2010)Gu, H., et al. Zhonghua Yan Ke Za Zhi 46(2):125-128(2010)DeAngelis, M.M., et al. Arch. Ophthalmol. 125(1):49-54(2007)McMahon, A., et al. Mol. Vis. 13, 258-272 (2007) :
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