TMOD1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P28289 |
---|---|
Clone Names | 100528148 |
Gene ID | 7111 |
---|---|
Other Names | Tropomodulin-1, Erythrocyte tropomodulin, E-Tmod, TMOD1, D9S57E, TMOD |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TMOD1 |
---|---|
Synonyms | D9S57E, TMOD |
Function | Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. |
Cellular Location | Cytoplasm, cytoskeleton. Note=In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574). |
Tissue Location | Highly expressed in the erythrocyte, heart and skeletal muscle |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
TMOD1 is a member of the tropomodulin family. Theencoded protein is an actin-capping protein that regulatestropomyosin by binding to its N-terminus, inhibitingdepolymerization and elongation of the pointed end of actinfilaments and thereby influencing the structure of the erythrocytemembrane skeleton. Multiple transcript variants encoding the sameprotein have been found for this gene.
References
Olsen, J.V., et al. Cell 127(3):635-648(2006)Kong, K.Y., et al. J. Biol. Chem. 281(14):9589-9599(2006)Vera, C., et al. Arch. Biochem. Biophys. 444(2):130-138(2005)Pawlak, G., et al. Int. J. Cancer 110(3):368-373(2004)Rho, S.B., et al. FEBS Lett. 557 (1-3), 57-63 (2004) :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.