|Other Names||Vesicular integral-membrane protein VIP36, Glycoprotein GP36b, Lectin mannose-binding 2, Vesicular integral-membrane protein 36, VIP36, LMAN2, C5orf8|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity).|
|Cellular Location||Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
LMAN2 is a type I transmembrane lectin thatshuttles between the endoplasmic reticulum, the Golgi apparatus andthe plasma membrane. The encoded protein binds high mannose typeglycoproteins and may facilitate their sorting, trafficking andquality control.
Reiterer, V., et al. Traffic 11(8):1044-1055(2010)Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010)Nawa, D., et al. Glycobiology 17(9):913-921(2007)Kawasaki, N., et al. J. Biochem. 141(2):221-229(2007)Kamiya, Y., et al. J. Biol. Chem. 280(44):37178-37182(2005)
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