|Other Names||Fc receptor-like protein 5, FcR-like protein 5, FcRL5, BXMAS1, Fc receptor homolog 5, FcRH5, Immune receptor translocation-associated protein 2, CD307e, FCRL5, FCRH5, IRTA2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil Expressed in many lymphoma cell lines and on hairy cell leukemia cells. Isoform 1, isoform 3, isoform 4 and isoform 5 are detected in lymph node, spleen, bone marrow, and small intestine with preponderance of isoform 3. Expressed in mature and memory B-cells and down-regulated in germinal center cells (at protein level)|
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FCRL5 is a member of the immunoglobulin receptorsuperfamily and the Fc-receptor like family. This gene and severalother Fc receptor-like gene members are clustered on the long armof chromosome 1. The encoded protein is a single-pass type Imembrane protein and contains 8 immunoglobulin-like C2-typedomains. This gene is implicated in B cell development andlymphomagenesis. Alternatively spliced transcript variants encodingdifferent isoforms have been identified.
Lee, J.E., et al. Cell Prolif. 43(4):378-384(2010)Simmonds, M.J., et al. Clin. Endocrinol. (Oxf) (2010) In press :Davila, S., et al. Genes Immun. 11(3):232-238(2010)Tang, X., et al. Tissue Antigens 74(4):314-316(2009)Kazemi, T., et al. Cancer Immunol. Immunother. 58(6):989-996(2009)
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