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GAB3 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8WWW8 |
|---|---|
| Clone Names | 100422040 |
| Gene ID | 139716 |
|---|---|
| Other Names | GRB2-associated-binding protein 3, GRB2-associated binder 3, Growth factor receptor bound protein 2-associated protein 3, GAB3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GAB3 |
|---|
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Provided below are standard protocols that you may find useful for product applications.
Background
GAB3 is a member of the GRB2-associated bindingprotein gene family. These proteins are scaffolding/dockingproteins that are involved in several growth factor and cytokinesignaling pathways, and they contain a pleckstrin homology domain,and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. Theprotein encoded by this gene facilitates macrophagedifferentiation. Two transcript variants encoding differentisoforms have been found for this gene.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Barrett, J.C., et al. Nat. Genet. 41(6):703-707(2009)Seiffert, M., et al. Mol. Cell. Biol. 23(7):2415-2424(2003)
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