|Other Names||GRB2-associated-binding protein 3, GRB2-associated binder 3, Growth factor receptor bound protein 2-associated protein 3, GAB3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
GAB3 is a member of the GRB2-associated bindingprotein gene family. These proteins are scaffolding/dockingproteins that are involved in several growth factor and cytokinesignaling pathways, and they contain a pleckstrin homology domain,and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. Theprotein encoded by this gene facilitates macrophagedifferentiation. Two transcript variants encoding differentisoforms have been found for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Barrett, J.C., et al. Nat. Genet. 41(6):703-707(2009)Seiffert, M., et al. Mol. Cell. Biol. 23(7):2415-2424(2003)
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