|Other Names||Collagen alpha-2(VI) chain, COL6A2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Collagen VI acts as a cell-binding protein.|
|Cellular Location||Secreted, extracellular space, extracellular matrix. Membrane; Peripheral membrane protein. Note=Recruited on membranes by CSPG4|
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COL6A2 is one of the three alpha chains of type VIcollagen, a beaded filament collagen found in most connectivetissues. The product of this gene contains several domains similarto von Willebrand Factor type A domains. These domains have beenshown to bind extracellular matrix proteins, an interaction thatexplains the importance of this collagen in organizing matrixcomponents. Mutations in this gene are associated with Bethlemmyopathy and Ullrich scleroatonic muscular dystrophy. Threetranscript variants have been identified for this gene. [providedby RefSeq].
Zhang, R.Z., et al. J. Biol. Chem. 285(13):10005-10015(2010)Bovolenta, M., et al. BMC Med. Genet. 11, 44 (2010) :Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)Freise, C., et al. Matrix Biol. 28(8):480-489(2009)Martoni, E., et al. Hum. Mutat. 30 (5), E662-E672 (2009) :
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