|Other Names||CD226 antigen, DNAX accessory molecule 1, DNAM-1, CD226, CD226, DNAM1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704). Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T- cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed by peripheral blood T-lymphocytes.|
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Provided below are standard protocols that you may find useful for product applications.
CD226 is a glycoprotein expressed on the surfaceof NK cells, platelets, monocytes and a subset of T cells. It is amember of the Ig-superfamily containing 2 Ig-like domains of theV-set. The protein mediates cellular adhesion of platelets andmegakaryocytic cells to vascular endothelial cells. The proteinalso plays a role in megakaryocytic cell maturation. [provided byRefSeq].
Lofgren, S.E., et al. Arthritis Rheum. 62(11):3404-3414(2010)Carlsten, M., et al. Leukemia 24(9):1607-1616(2010)Plant, D., et al. Ann. Rheum. Dis. 69(8):1548-1553(2010)Alcina, A., et al. Genes Immun. 11(5):439-445(2010)Jian, J.L., et al. J. Biol. Chem. 281(39):28731-28736(2006)
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