Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
CD226 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q15762 |
|---|---|
| Clone Names | 100430144 |
| Gene ID | 10666 |
|---|---|
| Other Names | CD226 antigen, DNAX accessory molecule 1, DNAM-1, CD226, CD226, DNAM1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CD226 |
|---|---|
| Synonyms | DNAM1 |
| Function | Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T- lymphocyte (CTL) and NK cell (PubMed:8673704). Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Expressed by peripheral blood T-lymphocytes. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
CD226 is a glycoprotein expressed on the surfaceof NK cells, platelets, monocytes and a subset of T cells. It is amember of the Ig-superfamily containing 2 Ig-like domains of theV-set. The protein mediates cellular adhesion of platelets andmegakaryocytic cells to vascular endothelial cells. The proteinalso plays a role in megakaryocytic cell maturation. [provided byRefSeq].
References
Lofgren, S.E., et al. Arthritis Rheum. 62(11):3404-3414(2010)Carlsten, M., et al. Leukemia 24(9):1607-1616(2010)Plant, D., et al. Ann. Rheum. Dis. 69(8):1548-1553(2010)Alcina, A., et al. Genes Immun. 11(5):439-445(2010)Jian, J.L., et al. J. Biol. Chem. 281(39):28731-28736(2006)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
