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IFT57 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9NWB7
Clone Names 100528288
Peptide ID 100528288
Additional Information
Gene ID 55081
Other Names Intraflagellar transport protein 57 homolog, Dermal papilla-derived protein 8, Estrogen-related receptor beta-like protein 1, HIP1-interacting protein, MHS4R2, IFT57, DERP8, ESRRBL1, HIPPI
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name IFT57
Synonyms DERP8, ESRRBL1, HIPPI
Function Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
Cellular Location Cytoplasm, cytoskeleton, cilium basal body. Note=Concentrates within the inner segment of cilia.
Tissue Location Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level)
Research Areas
Citations (0)

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Background

IFT57 is required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.

References

Gdynia, G., et al. Apoptosis 13(3):437-447(2008)Majumder, P., et al. Biochem. Biophys. Res. Commun. 353(1):80-85(2007)Banerjee, M., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62 (PT 12), 1247-1250 (2006) :Majumder, P., et al. Neurobiol. Dis. 22(2):242-256(2006)Fan, Y., et al. Nat. Genet. 36(9):989-993(2004)

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$ 80.00
Cat# BP16420a
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