|Other Names||Sodium-coupled neutral amino acid transporter 1, Amino acid transporter A1, N-system amino acid transporter 2, Solute carrier family 38 member 1, System A amino acid transporter 1, System N amino acid transporter 1, SLC38A1, ATA1, NAT2, SAT1, SNAT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ATA1, NAT2, SAT1, SNAT1|
|Function||Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA.|
|Cellular Location||Cell membrane; Multi-pass membrane protein Note=Restricted to the somatodendritic compartment of neurons Found in the cellular processes of neurons in the developing brain (By similarity).|
|Tissue Location||Expressed in the cerebral cortex by pyramidal and GABAergic neurons, astrocytes and other non-neuronal cells (at protein level). Expressed in placenta, heart, lung, skeletal muscle, spleen, stomach and testis.|
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Provided below are standard protocols that you may find useful for product applications.
Amino acid transporters play essential roles in the uptakeof nutrients, production of energy, chemical metabolism,detoxification, and neurotransmitter cycling. SLC38A1 is animportant transporter of glutamine, an intermediate in thedetoxification of ammonia and the production of urea. Glutamineserves as a precursor for the synaptic transmitter, glutamate (Guet al., 2001 [PubMed 11325958]).
Desforges, M., et al. Biochem. Biophys. Res. Commun. 398(1):130-134(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Kim, S., et al. Mol. Psychiatry (2010) In press :Ernst, C., et al. Neuroscience 162(2):415-422(2009)Potkin, S.G., et al. PLoS ONE 4 (8), E6501 (2009) :
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