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SLC38A1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H2H9 |
|---|---|
| Clone Names | 100603029 |
| Gene ID | 81539 |
|---|---|
| Other Names | Sodium-coupled neutral amino acid transporter 1, Amino acid transporter A1, N-system amino acid transporter 2, Solute carrier family 38 member 1, System A amino acid transporter 1, System N amino acid transporter 1, SLC38A1, ATA1, NAT2, SAT1, SNAT1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC38A1 |
|---|---|
| Function | Symporter that cotransports short-chain neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:20599747, PubMed:10891391). The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient (PubMed:10891391). Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (By similarity). May also contributes to amino acid transport in placental trophoblasts (PubMed:20599747). Also regulates synaptic plasticity (PubMed:12388062). |
| Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9JM15} Note=Restricted to the somatodendritic compartment of neurons. Found in the cellular processes of neurons in the developing brain {ECO:0000250|UniProtKB:Q9JM15} |
| Tissue Location | Expressed in the cerebral cortex by pyramidal and GABAergic neurons, astrocytes and other non-neuronal cells (at protein level). Expressed in placenta, heart, lung, skeletal muscle, spleen, stomach and testis (PubMed:10891391, PubMed:12388062, PubMed:15054072, PubMed:16148032). Highly expressed in cytotrophoblast cells from term placenta (PubMed:20599747). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Amino acid transporters play essential roles in the uptakeof nutrients, production of energy, chemical metabolism,detoxification, and neurotransmitter cycling. SLC38A1 is animportant transporter of glutamine, an intermediate in thedetoxification of ammonia and the production of urea. Glutamineserves as a precursor for the synaptic transmitter, glutamate (Guet al., 2001 [PubMed 11325958]).
References
Desforges, M., et al. Biochem. Biophys. Res. Commun. 398(1):130-134(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Kim, S., et al. Mol. Psychiatry (2010) In press :Ernst, C., et al. Neuroscience 162(2):415-422(2009)Potkin, S.G., et al. PLoS ONE 4 (8), E6501 (2009) :
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