|Other Names||M-phase phosphoprotein 6, MPHOSPH6, MPP6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and may play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D.|
|Cellular Location||Nucleus, nucleolus. Cytoplasm. Note=Cytoplasmic in M phase|
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Provided below are standard protocols that you may find useful for product applications.
Progression of cells from interphase to mitosis involves alterations in cell structures and activities. The transition from G2 to M phase is induced by M phase promoting factor, or MPF. In M phase, many proteins are phosphorylated directly by MPF or indirectly by kinases activated by MPF. These M phase phosphoproteins (MPPs, or MPHOSPHs) permit disassembly of interphase structures and generation of M phase enzymatic activities and structures.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)Org, E., et al. Hum. Mol. Genet. 18(12):2288-2296(2009)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)
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