|Other Names||Probable ATP-dependent RNA helicase DDX28, Mitochondrial DEAD box protein 28, DDX28, MDDX28|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function (PubMed:25683708, PubMed:25683715). May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity (PubMed:11350955).|
|Cellular Location||Nucleus. Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid. Mitochondrion matrix. Note=Transported between these two compartments. Nuclear localization depends on active RNA polymerase II transcription. Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids|
|Tissue Location||Expressed in all tissues tested, including brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, leukocytes, colon, small intestine, ovary and prostate|
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Provided below are standard protocols that you may find useful for product applications.
DEAD box proteins, characterized by the conserved motifAsp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They areimplicated in a number of cellular processes involving alterationof RNA secondary structure, such as translation initiation, nuclearand mitochondrial splicing, and ribosome and spliceosome assembly.Based on their distribution patterns, some members of the DEAD boxprotein family are believed to be involved in embryogenesis,spermatogenesis, and cellular growth and division. This gene isintronless. It encodes an RNA-dependent ATPase. The encoded proteinis localized in the mitochondria and the nucleus, and can betransported between the mitochondria and the nucleus. [provided byRefSeq].
Bogenhagen, D.F., et al. J. Biol. Chem. 283(6):3665-3675(2008)Valgardsdottir, R., et al. J. Biol. Chem. 278(23):21146-21154(2003)Valgardsdottir, R., et al. J. Biol. Chem. 276(34):32056-32063(2001)Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)Loftus, B.J., et al. Genomics 60(3):295-308(1999)
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