|Other Names||E3 ubiquitin-protein ligase DTX3L, 632-, B-lymphoma- and BAL-associated protein, Protein deltex-3-like, Rhysin-2, Rhysin2, DTX3L, BBAP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post- translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1- dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.|
|Cellular Location||Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage in a PARP1-dependent manner|
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Provided below are standard protocols that you may find useful for product applications.
DTX3L functions as an E3 ubiquitin ligase (Takeyama etal., 2003 [PubMed 12670957]).
Yan, Q., et al. Mol. Cell 36(1):110-120(2009)Wilting, S.M., et al. Genes Chromosomes Cancer 47(10):890-905(2008)Juszczynski, P., et al. Mol. Cell. Biol. 26(14):5348-5359(2006)Takeyama, K., et al. J. Biol. Chem. 278(24):21930-21937(2003)
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