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DTX3L Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8TDB6
Clone Names 100603283
Peptide ID 100603283
Additional Information
Gene ID 151636
Other Names E3 ubiquitin-protein ligase DTX3L, 632-, B-lymphoma- and BAL-associated protein, Protein deltex-3-like, Rhysin-2, Rhysin2, DTX3L, BBAP
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DTX3L
Synonyms BBAP
Function Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post- translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1- dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.
Cellular Location Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage in a PARP1-dependent manner
Research Areas
Citations (0)

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DTX3L functions as an E3 ubiquitin ligase (Takeyama etal., 2003 [PubMed 12670957]).


Yan, Q., et al. Mol. Cell 36(1):110-120(2009)Wilting, S.M., et al. Genes Chromosomes Cancer 47(10):890-905(2008)Juszczynski, P., et al. Mol. Cell. Biol. 26(14):5348-5359(2006)Takeyama, K., et al. J. Biol. Chem. 278(24):21930-21937(2003)

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$ 80.00
Cat# BP16451c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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