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SATB2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UPW6 |
|---|---|
| Clone Names | 100507077 |
| Gene ID | 23314 |
|---|---|
| Other Names | DNA-binding protein SATB2, Special AT-rich sequence-binding protein 2, SATB2, KIAA1034 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SATB2 |
|---|---|
| Synonyms | KIAA1034 |
| Function | Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double- stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. |
| Cellular Location | Nucleus matrix {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00374, ECO:0000269|PubMed:14701874} |
| Tissue Location | High expression in adult brain, moderate expression in fetal brain, and weak expression in adult liver, kidney, and spinal cord and in select brain regions, including amygdala, corpus callosum, caudate nucleus, and hippocampus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a DNA binding protein that specificallybinds nuclear matrix attachment regions. The encoded protein isinvolved in transcription regulation and chromatin remodeling.Defects in this gene are associated with isolated cleft palate andmental retardation. Alternate splicing results in multipletranscript variants that encode the same protein. [provided byRefSeq].
References
McGovern, D.P., et al. Nat. Genet. 42(4):332-337(2010)Carter, T.C., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(2):84-93(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Rosenfeld, J.A., et al. PLoS ONE 4 (8), E6568 (2009) :Beaty, T.H., et al. Hum. Genet. 120(4):501-518(2006)
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