|Other Names||Bone morphogenetic protein receptor type-1A, BMP type-1A receptor, BMPR-1A, Activin receptor-like kinase 3, ALK-3, BMP-2/BMP-4 receptor, Serine/threonine-protein kinase receptor R5, SKR5, CD292, Bmpr1a, Acvrlk3, Bmpr|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction (PubMed:24098149). Mediates induction of adipogenesis by GDF6 (PubMed:23527555).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4.
Drogat, B., et al. Blood 116(12):2141-2151(2010)Leung, A.W., et al. Dev. Dyn. 239(9):2319-2329(2010)Mira, H., et al. Cell Stem Cell 7(1):78-89(2010)Libusova, L., et al. Development 137(14):2297-2305(2010)Caronia, G., et al. J. Neurosci. 30(18):6291-6301(2010)
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