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MTA3 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BTC8 |
|---|---|
| Clone Names | 100528219 |
| Gene ID | 57504 |
|---|---|
| Other Names | Metastasis-associated protein MTA3, MTA3, KIAA1266 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MTA3 |
|---|---|
| Synonyms | KIAA1266 |
| Function | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:12705869, PubMed:28977666). Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels (PubMed:12705869). Contributes to transcriptional repression by BCL6 (PubMed:15454082). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:12705869, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}. Cytoplasm {ECO:0000250|UniProtKB:Q924K8} |
| Tissue Location | Expressed in germinal centers of lymphoid tissues. No expression in nonepithelial cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
MTA3 plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels.
References
Bruning, A., et al. Histochem. Cell Biol. 132(1):33-38(2009)Lasky-Su, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1345-1354 (2008) :Zhang, H., et al. Genes Dev. 20(21):2943-2948(2006)Yu, J.C., et al. J. Biomed. Sci. 13(3):419-432(2006)Fujita, N., et al. Cell 119(1):75-86(2004)
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