|Other Names||Visual system homeobox 2, Ceh-10 homeodomain-containing homolog, Homeobox protein CHX10, VSX2, CHX10, HOX10|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity).|
|Tissue Location||Abundantly expressed in retinal neuroblasts during eye development and in the inner nuclear layer of the adult retina. Within this layer, expression is stronger in the outer margin where bipolar cells predominate|
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This gene encodes a homeobox protein originally describedas a retina-specific transcription factor. Mutations in this geneare associated with microphthalmia, cataracts and irisabnormalities.
Gonzalez-Rodriguez, J., et al. Br J Ophthalmol 94(8):1100-1104(2010)Iseri, S.U., et al. Hum. Genet. 128(1):51-60(2010)Reichman, S., et al. Hum. Mol. Genet. 19(2):250-261(2010)Nagel, S., et al. Mol. Cancer 9, 151 (2010) :Zhang, X., et al. Mol. Vis. 15, 2911-2918 (2009) :
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