|Other Names||Disintegrin and metalloproteinase domain-containing protein 23, ADAM 23, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3, MDC-3, ADAM23, MDC3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in the brain and weakly expressed in the heart. In the brain, expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole.|
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This gene encodes a member of the ADAM (a disintegrin andmetalloprotease domain) family. Members of this family aremembrane-anchored proteins structurally related to snake venomdisintegrins, and have been implicated in a variety of biologicalprocesses involving cell-cell and cell-matrix interactions,including fertilization, muscle development, and neurogenesis. Thisgene is highly expressed in the brain and may function as anintegrin ligand in the brain.
Pan, Q., et al. Biochem. Biophys. Res. Commun. 401(2):306-312(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Ferreira, M.A., et al. Allergy 64(11):1623-1628(2009)Costa, M.D., et al. Neurosci. Lett. 461(1):16-20(2009)Verbisck, N.V., et al. Cancer Res. 69(13):5546-5552(2009)
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