|Other Names||G patch domain and KOW motifs-containing protein, G patch domain-containing protein 5, Protein MOS2 homolog, Protein T54, GPKOW, GPATC5, GPATCH5, T54|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPATC5, GPATCH5, T54|
|Function||RNA-binding protein involved in pre-mRNA splicing.|
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T54, also known as GPKOW (G patch domain and KOW motifs), GPATC5 or GPATCH5 (G patch domain-containing protein 5), is a potential RNA-binding protein consisting of one central G patch domain and two C-terminal KOW domains. T54 is a 476 amino acid protein belonging to the MOS2 family. It is a mammalian homolog of the Arabidopsis thaliana MOS2 (modifier of SNC1, 2) nuclear protein that is required for innate immunity. Similar to A. thaliana MOS2, T54 localizes to the nucleus and contains G patch and KOW domains, suggesting that T54 may play a similar role in mammalian innate immunity.
Lamesch, P., et al. Genomics 89(3):307-315(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Zhang, Y., et al. Curr. Biol. 15(21):1936-1942(2005)Schindelhauer, D., et al. Genome Res. 6(11):1056-1069(1996)
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