|Other Names||C-C chemokine receptor-like 2, Chemokine receptor CCR11, Chemokine receptor X, Putative MCP-1 chemokine receptor, CCRL2, CCR11, CCR6, CKRX, CRAM, HCR|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CCR11, CCR6, CKRX, CRAM, HCR|
|Function||Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T- cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B-cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients.|
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This gene encodes a chemokine receptor like protein, whichis predicted to be a seven transmembrane protein and most closelyrelated to CCR1. Chemokines and their receptors mediated signaltransduction are critical for the recruitment of effector immunecells to the site of inflammation. This gene is expressed at highlevels in primary neutrophils and primary monocytes, and is furtherupregulated on neutrophil activation and during monocyte tomacrophage differentiation. The function of this gene is unknown.This gene is mapped to the region where the chemokine receptor genecluster is located.
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)Leick, M., et al. Immunology 129(4):536-546(2010)Segat, L., et al. Vaccine 28(10):2201-2206(2010)Zabel, B.A., et al. J. Exp. Med. 205(10):2207-2220(2008)
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