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ARNT2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9HBZ2 |
|---|---|
| Clone Names | 100617188 |
| Gene ID | 9915 |
|---|---|
| Other Names | Aryl hydrocarbon receptor nuclear translocator 2, ARNT protein 2, Class E basic helix-loop-helix protein 1, bHLHe1, ARNT2, BHLHE1, KIAA0307 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ARNT2 |
|---|---|
| Synonyms | BHLHE1, KIAA0307 |
| Function | Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function (PubMed:24022475). Specifically recognizes the xenobiotic response element (XRE). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:24465693} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of thebasic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily oftranscription factors. The encoded protein acts as a partner forseveral sensor proteins of the bHLH-PAS family, formingheterodimers with the sensor proteins that bind regulatory DNAsequences in genes responsive to developmental and environmentalstimuli. Under hypoxic conditions, the encoded protein complexeswith hypoxia-inducible factor 1alpha in the nucleus and thiscomplex binds to hypoxia-responsive elements in enhancers andpromoters of oxygen-responsive genes. A highly similar protein inmouse forms functional complexes with both aryl hydrocarbonreceptors and Single-minded proteins, suggesting addition roles forthe encoded protein in the metabolism of xenobiotic compounds andthe regulation of neurogenesis, respectively.
References
Ramirez, J.M., et al. Eur. J. Immunol. 40(9):2450-2459(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Chakrabarti, B., et al. Autism Res 2(3):157-177(2009)Ferreira, M.A., et al. Nat. Genet. 40(9):1056-1058(2008)Martinez, V., et al. Breast Cancer Res. Treat. 110(3):521-530(2008)
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