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ATF3 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P18847
Clone Names 100507225
Peptide ID 100507225
Additional Information
Gene ID 467
Other Names Cyclic AMP-dependent transcription factor ATF-3, cAMP-dependent transcription factor ATF-3, Activating transcription factor 3, ATF3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATF3
Function This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978, ECO:0000269|PubMed:12034827}
Research Areas
Citations (0)

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Activating transcription factor 3 is a member of themammalian activation transcription factor/cAMP responsiveelement-binding (CREB) protein family of transcription factors.Multiple transcript variants encoding two different isoforms havebeen found for this gene. The longer isoform represses rather thanactivates transcription from promoters with ATF binding elements.The shorter isoform (deltaZip2) lacks the leucine zipperprotein-dimerization motif and does not bind to DNA, and itstimulates transcription presumably by sequestering inhibitoryco-factors away from the promoter. It is possible that alternativesplicing of the ATF3 gene may be physiologically important in theregulation of target genes.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Lee, S.H., et al. Oncogene 29(37):5182-5192(2010)Park, H.J., et al. Biochem. Biophys. Res. Commun. 400(1):72-77(2010)Wu, X., et al. Nature 465(7296):368-372(2010)Koh, I.U., et al. FEBS J. 277(10):2304-2317(2010)

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$ 80.00
Cat# BP16577b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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