ATF3 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P18847 |
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Clone Names | 100507225 |
Gene ID | 467 |
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Other Names | Cyclic AMP-dependent transcription factor ATF-3, cAMP-dependent transcription factor ATF-3, Activating transcription factor 3, ATF3 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ATF3 {ECO:0000303|PubMed:7515060, ECO:0000312|HGNC:HGNC:785} |
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Function | This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:12034827} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Activating transcription factor 3 is a member of themammalian activation transcription factor/cAMP responsiveelement-binding (CREB) protein family of transcription factors.Multiple transcript variants encoding two different isoforms havebeen found for this gene. The longer isoform represses rather thanactivates transcription from promoters with ATF binding elements.The shorter isoform (deltaZip2) lacks the leucine zipperprotein-dimerization motif and does not bind to DNA, and itstimulates transcription presumably by sequestering inhibitoryco-factors away from the promoter. It is possible that alternativesplicing of the ATF3 gene may be physiologically important in theregulation of target genes.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Lee, S.H., et al. Oncogene 29(37):5182-5192(2010)Park, H.J., et al. Biochem. Biophys. Res. Commun. 400(1):72-77(2010)Wu, X., et al. Nature 465(7296):368-372(2010)Koh, I.U., et al. FEBS J. 277(10):2304-2317(2010)
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