|Other Names||Histone H2B type 1-D, HIRA-interacting protein 2, Histone H2B1 B, Histone H2Bb, H2B/b, HIST1H2BD, H2BFB, HIRIP2|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|
|Cellular Location||Nucleus. Chromosome.|
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Histones are basic nuclear proteins that are responsiblefor the nucleosome structure of the chromosomal fiber ineukaryotes. Nucleosomes consist of approximately 146 bp of DNAwrapped around a histone octamer composed of pairs of each of thefour core histones (H2A, H2B, H3, and H4). The chromatin fiber isfurther compacted through the interaction of a linker histone, H1,with the DNA between the nucleosomes to form higher order chromatinstructures. This gene is intronless and encodes a member of thehistone H2B family. Two transcripts that encode the same proteinhave been identified for this gene, which is found in the largehistone gene cluster on chromosome 6p22-p21.3. [provided byRefSeq].
Kim, S.C., et al. Mol. Cell 23(4):607-618(2006)Beck, H.C., et al. Mol. Cell Proteomics 5(7):1314-1325(2006)Pavri, R., et al. Cell 125(4):703-717(2006)Bonenfant, D., et al. Mol. Cell Proteomics 5(3):541-552(2006)Siuti, N., et al. J. Proteome Res. 5(2):233-239(2006)
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