|Other Names||Troponin T, cardiac muscle, TnTc, Cardiac muscle troponin T, cTnT, TNNT2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.|
|Tissue Location||Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart|
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The protein encoded by this gene is thetropomyosin-binding subunit of the troponin complex, which islocated on the thin filament of striated muscles and regulatesmuscle contraction in response to alterations in intracellularcalcium ion concentration. Mutations in this gene have beenassociated with familial hypertrophic cardiomyopathy as well aswith dilated cardiomyopathy. Transcripts for this gene undergoalternative splicing that results in many tissue-specific isoforms,however, the full-length nature of some of these variants has notyet been determined.
Millat, G., et al. Clin. Chim. Acta 411 (23-24), 1983-1991 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Millat, G., et al. Eur J Med Genet 53(5):261-267(2010)Watt, K.D., et al. Liver Transpl. 16(8):990-998(2010)Koide, K., et al. Heart Vessels 25(3):217-222(2010)
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