|Other Names||Taste receptor type 2 member 31, T2R31, Taste receptor type 2 member 44, T2R44, Taste receptor type 2 member 53, T2R53, TAS2R31, TAS2R44|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). Activated by the sulfonyl amide sweeteners saccharin and acesulfame K.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells|
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Provided below are standard protocols that you may find useful for product applications.
TAS2R44 belongs to the large TAS2R receptor family. TAS2Rsare expressed on the surface of taste receptor cells and mediatethe perception of bitterness through a G protein-coupled secondmessenger pathway (Conte et al., 2002 [PubMed 12584440]). Forfurther information on TAS2Rs, see MIM 604791.
Pronin, A.N., et al. Curr. Biol. 17(16):1403-1408(2007)Fischer, A., et al. Mol. Biol. Evol. 22(3):432-436(2005)Kuhn, C., et al. J. Neurosci. 24(45):10260-10265(2004)Pronin, A.N., et al. Chem. Senses 29(7):583-593(2004)Zhang, Y., et al. Cell 112(3):293-301(2003)
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