|Other Names||Protein lifeguard 2, Fas apoptotic inhibitory molecule 2, Neural membrane protein 35, Transmembrane BAX inhibitor motif-containing protein 2, FAIM2, KIAA0950, LFG, LFG2, NMP35, TMBIM2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0950, LFG, LFG2, NMP35, TMBIM2|
|Function||Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Membrane raft. Cell junction, synapse, postsynaptic cell membrane|
|Tissue Location||Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especially in the hippocampus.|
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Provided below are standard protocols that you may find useful for product applications.
FAIM2 protects cells uniquely from Fas-induced apoptosis.
Melen, E., et al. J. Allergy Clin. Immunol. 126(3):631-637(2010)Bucan, V., et al. Cell. Mol. Biol. Lett. 15(2):296-310(2010)Ng, M.C., et al. J. Clin. Endocrinol. Metab. 95(5):2418-2425(2010)Li, S., et al. Am. J. Clin. Nutr. 91(1):184-190(2010)Hotta, K., et al. J. Hum. Genet. 54(12):727-731(2009)
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