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FAIM2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BWQ8 |
|---|---|
| Clone Names | 100603147 |
| Gene ID | 23017 |
|---|---|
| Other Names | Protein lifeguard 2, Fas apoptotic inhibitory molecule 2, Neural membrane protein 35, Transmembrane BAX inhibitor motif-containing protein 2, FAIM2, KIAA0950, LFG, LFG2, NMP35, TMBIM2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | FAIM2 |
|---|---|
| Synonyms | KIAA0950, LFG, LFG2, NMP35, TMBIM2 |
| Function | Antiapoptotic protein which protects cells uniquely from Fas- induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Membrane raft Postsynaptic cell membrane |
| Tissue Location | Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especially in the hippocampus. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
FAIM2 protects cells uniquely from Fas-induced apoptosis.
References
Melen, E., et al. J. Allergy Clin. Immunol. 126(3):631-637(2010)Bucan, V., et al. Cell. Mol. Biol. Lett. 15(2):296-310(2010)Ng, M.C., et al. J. Clin. Endocrinol. Metab. 95(5):2418-2425(2010)Li, S., et al. Am. J. Clin. Nutr. 91(1):184-190(2010)Hotta, K., et al. J. Hum. Genet. 54(12):727-731(2009)
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