|Other Names||Axonemal dynein light intermediate polypeptide 1, Inner dynein arm light chain, axonemal, hp28, DNALI1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a dynamic role in flagellar motility.|
|Tissue Location||Expressed in many tissues. A smaller 0.9 kb and a larger 2.5 kb transcripts were detected at the highest level in the testis, at medium levels in the prostate, heart, liver, lung and pancreas, at low levels in the ovary, skeletal muscle and small intestine. Not detected in spleen, colon epithelium, thymus or peripheral blood leukocytes. The 0.9 kb transcript is expressed at a 20-fold higher level than the 2.5 kb transcript in the testis|
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Provided below are standard protocols that you may find useful for product applications.
This gene is the human homolog of the Chlamydomonas innerdynein arm gene, p28. The precise function of this gene is notknown, however, it is a potential candidate for immotile ciliasyndrome (ICS). Ultrastructural defects of the inner dynein armsare seen in patients with ICS. Immotile mutant strains ofChlamydomonas, a biflagellated algae, exhibit similar defects.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Lamesch, P., et al. Genomics 89(3):307-315(2007)Combs, J., et al. Proc. Natl. Acad. Sci. U.S.A. 103(40):14883-14888(2006)Kastury, K., et al. J. Clin. Endocrinol. Metab. 82(9):3047-3053(1997)
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