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TMEM120B Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | A0PK00 |
|---|---|
| Clone Names | 100422268 |
| Gene ID | 144404 |
|---|---|
| Other Names | Transmembrane protein 120B, TMEM120B |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TMEM120B (HGNC:32008) |
|---|---|
| Function | Necessary for efficient adipogenesis. Does not show ion channel activity. |
| Cellular Location | Nucleus inner membrane {ECO:0000250|UniProtKB:Q3TA38}; Multi-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
TMEM120B (Transmembrane protein 120B) is a 339 amino acid multi-pass membrane protein that is encoded by a gene that maps to human chromosome 12. Encoding over 1,100 genes within 132 million bases, chromosome 12 makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Trynka, G., et al. Gut 58(8):1078-1083(2009)
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