|Other Names||Breast carcinoma-amplified sequence 1, Amplified and overexpressed in breast cancer, Novel amplified in breast cancer 1, BCAS1, AIBC1, NABC1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Expressed in brain and prostate, and at lower levels in testis, intestine and colon. Overexpressed in most breast cancer cell lines and down-regulated in some colorectal tumors.|
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This gene resides in a region at 20q13 which is amplifiedin a variety of tumor types and associated with more aggressivetumor phenotypes. Among the genes identified from this region, itwas found to be highly expressed in three amplified breast cancercell lines and in one breast tumor without amplification at20q13.2. However, this gene is not in the common region of maximalamplification and its expression was not detected in the breastcancer cell line MCF7, in which this region is highly amplified.Although not consistently expressed, this gene is a candidateoncogene.
Rose, J. Phd, et al. Mol. Med. (2010) In press :Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Burmester, J.K., et al. Hum. Hered. 57(4):172-178(2004)Beardsley, D.I., et al. Exp. Cell Res. 290(2):402-413(2003)Deloukas, P., et al. Nature 414(6866):865-871(2001)
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