|Other Names||Excitatory amino acid transporter 4, Sodium-dependent glutamate/aspartate transporter, Solute carrier family 1 member 6, SLC1A6, EAAT4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7791878). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Brain. Expressed densely and selectively in cell bodies of Purkinje cells|
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Transports L-glutamate and also L-and D-aspartate. Seems to act as a symport by cotransporting sodium.
Kovermann, P., et al. J. Biol. Chem. 285(31):23676-23686(2010)Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :Need, A.C., et al. Eur. J. Hum. Genet. 17(7):946-957(2009)Rajamanickam, J., et al. J. Neurochem. 102(3):858-866(2007)
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