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SLC1A6 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P48664
Clone Names 100603067
Peptide ID 100603067
Additional Information
Gene ID 6511
Other Names Excitatory amino acid transporter 4, Sodium-dependent glutamate/aspartate transporter, Solute carrier family 1 member 6, SLC1A6, EAAT4
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC1A6
Synonyms EAAT4
Function Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7791878). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Brain. Expressed densely and selectively in cell bodies of Purkinje cells
Research Areas
Citations (0)

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Background

Transports L-glutamate and also L-and D-aspartate. Seems to act as a symport by cotransporting sodium.

References

Kovermann, P., et al. J. Biol. Chem. 285(31):23676-23686(2010)Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :Need, A.C., et al. Eur. J. Hum. Genet. 17(7):946-957(2009)Rajamanickam, J., et al. J. Neurochem. 102(3):858-866(2007)

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$ 80.00
Cat# BP16635a
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