|Other Names||RPA-interacting protein, hRIP, RPAIN, RIP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.|
|Cellular Location||Isoform 1: Cytoplasm. Nucleus.|
|Tissue Location||Widely expressed. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis, prostate, thymus and spleen|
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Provided below are standard protocols that you may find useful for product applications.
RPAIN mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Dagle, J.M., et al. Pediatrics 123(4):1116-1123(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Park, J., et al. Mol. Cell. Biol. 25(18):8202-8214(2005)Chen, J.Z., et al. DNA Cell Biol. 24(7):464-469(2005)
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