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RNF103 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O00237
Clone Names 100603151
Peptide ID 100603151
Additional Information
Other Names E3 ubiquitin-protein ligase RNF103, 632-, KF-1, hKF-1, RING finger protein 103, Zinc finger protein 103 homolog, Zfp-103, RNF103, ZFP103
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RNF103
Synonyms ZFP103
Function Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location Highly expressed in the normal cerebellum but not in the cerebral cortex. EMBL; D76444; BAA19739.1; -; mRNA EMBL; AB052743; BAB20900.1; -; Genomic_DNA EMBL; AK314180; BAG36861.1; -; mRNA EMBL; AC015971; AAX93079.1; -; Genomic_DNA EMBL; BC035053; AAH35053.1; -; mRNA EMBL; BC110333; AAI10334.1; -; mRNA CCDS; CCDS33237.1; - PIR; JC5392; JC5392 RefSeq; NP_001185880.1; NM_001198951.1 RefSeq; NP_001185881.1; NM_001198952.1 RefSeq; NP_005658.1; NM_005667.3 UniGene; Hs.469199; - UniGene; Hs.731426; - ProteinModelPortal; O00237; - SMR; O00237; - BioGrid; 113601; 13 IntAct; O00237; 9 STRING; 9606.ENSP00000237455; - iPTMnet; O00237; - PhosphoSitePlus; O00237; - BioMuta; RNF103; - PaxDb; O00237; - PeptideAtlas; O00237; - PRIDE; O00237; - ProteomicsDB; 47801; - DNASU; 7844; - Ensembl; ENST00000237455; ENSP00000237455; ENSG00000239305 GeneID; 7844; - KEGG; hsa:7844; - UCSC; uc002srn.4; human CTD; 7844; - DisGeNET; 7844; - EuPathDB; HostDB:ENSG00000239305.6; - GeneCards; RNF103; - HGNC; HGNC:12859; RNF103 HPA; HPA057922; - MIM; 602507; gene neXtProt; NX_O00237; - OpenTargets; ENSG00000239305; - PharmGKB; PA37448; - eggNOG; KOG0800; Eukaryota eggNOG; ENOG41121N2; LUCA GeneTree; ENSGT00390000006413; - HOGENOM; HOG000006578; - HOVERGEN; HBG054144; - InParanoid; O00237; - KO; K15695; - OMA; GKVHWEK; - OrthoDB; EOG091G0EZD; - PhylomeDB; O00237; - TreeFam; TF329229; - Reactome; R-HSA-901032; ER Quality Control Compartment (ERQC) UniPathway; UPA00143; - GenomeRNAi; 7844; - PRO; PR:O00237; - Proteomes; UP000005640; Chromosome 2 Bgee; ENSG00000239305; - CleanEx; HS_RNF103; - Genevisible; O00237; HS GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome GO; GO:0044322; C:endoplasmic reticulum quality control compartment; IEA:GOC GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW GO; GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB GO; GO:0007417; P:central nervous system development; TAS:ProtInc GO; GO:1904380; P:endoplasmic reticulum mannose trimming; TAS:Reactome GO; GO:0016567; P:protein ubiquitination; IDA:UniProtKB GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IDA:UniProtKB Gene3D;; -; 1 InterPro; IPR001841; Znf_RING InterPro; IPR013083; Znf_RING/FYVE/PHD Pfam; PF13639; zf-RING_2; 1 SMART; SM00184; RING; 1 PROSITE; PS50089; ZF_RING_2; 1 1: Evidence at protein level; Complete proteome; Endoplasmic reticulum; Membrane; Metal-binding; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Ubl conjugation pathway; Zinc; Zinc-finger CHAIN 1 685 E3 ubiquitin-protein ligase RNF103 /FTId=PRO_0000056084 TRANSMEM 6 26 Helical. TRANSMEM 326 346 Helical. TRANSMEM 366 386 Helical. TRANSMEM 411 431 Helical. ZN_FING 621 663 RING-type. {ECO:0000255|PROSITE- ProRule:PRU00175} MUTAGEN 621 621 C->S: Loss of E2-dependent ubiquitination CONFLICT 22 22 F -> L (in Ref. 3; BAG36861) CONFLICT 251 251 S -> P (in Ref. 5; AAH35053) CONFLICT 287 287 S -> P (in Ref. 3; BAG36861) CONFLICT 502 502 P -> H (in Ref. 5; AAH35053) SEQUENCE 685 AA; 79405 MW; 5AE7283EB38F533F CRC64; MWLKLFFLLL YFLVLFVLAR FFEAIVWYET GIFATQLVDP VALSFKKLKT ILECRGLGYS GLPEKKDVRE LVEKSGDLME GELYSALKEE EASESVSSTN FSGEMHFYEL VEDTKDGIWL VQVIANDRSP LVGKIHWEKM VKKVSRFGIR TGTFNCSSDP RYCRRRGWVR STLIMSVPQT STSKGKVMLK EYSGRKIEVE HIFKWITAHA ASRIKTIYNA EHLKEEWNKS DQYWLKIYLF ANLDQPPAFF SALSIKFTGR VEFIFVNVEN WDNKSYMTDI GIYNMPSYIL RTPEGIYRYG NHTGEFISLQ AMDSFLRSLQ PEVNDLFVLS LVLVNLMAWM DLFITQGATI KRFVVLISTL GTYNSLLIIS WLPVLGFLQL PYLDSFYEYS LKLLRYSNTT TLASWVRADW MFYSSHPALF LSTYLGHGLL IDYFEKKRRR NNNNDEVNAN NLEWLSSLWD WYTSYLFHPI ASFQNFPVES DWDEDPDLFL ERLAFPDLWL HPLIPTDYIK NLPMWRFKCL GVQSEEEMSE GSQDTENDSE SENTDTLSSE KEVFEDKQSV LHNSPGTASH CDAEACSCAN KYCQTSPCER KGRSYGSYNT NEDMEPDWLT WPADMLHCTE CVVCLENFEN GCLLMGLPCG HVFHQNCIVM WLAGGRHCCP VCRWPSYKKK QPYAQHQPLS NDVPS
Research Areas
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The protein encoded by this gene contains a RING-H2finger, a motif known to be involved in protein-protein andprotein-DNA interactions. This gene is highly expressed in normalcerebellum, but not in the cerebral cortex. The expression of therat counterpart in the frontal cortex and hippocampus was shown tobe induced by elctroconvulsive treatment (ECT) as well as chronicantidepressant treatment, suggesting that this gene may be amolecular target for ECT and antidepressants. The protein is aubiquitin ligase that functions in the endoplasmicreticulum-associated degradation pathway. Alternative splicing ofthis gene results in multiple transcript variants. Read-throughtranscription also exists between this gene and the downstreamVPS24 (vacuolar protein sorting 24 homolog) gene. [provided byRefSeq].


Scheper, J., et al. Proteins 74(1):92-103(2009)Maruyama, Y., et al. Biochem. Biophys. Res. Commun. 374(4):737-741(2008)Yang, Y., et al. Meth. Enzymol. 398, 103-112 (2005) :Nishioka, G., et al. J Neural Transm 110(3):277-285(2003)Yamada, M., et al. Biochem. Biophys. Res. Commun. 278(1):150-157(2000)

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Cat# BP16642c
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