|Other Names||E3 ubiquitin-protein ligase RNF103, 632-, KF-1, hKF-1, RING finger protein 103, Zinc finger protein 103 homolog, Zfp-103, RNF103, ZFP103|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in the normal cerebellum but not in the cerebral cortex.|
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The protein encoded by this gene contains a RING-H2finger, a motif known to be involved in protein-protein andprotein-DNA interactions. This gene is highly expressed in normalcerebellum, but not in the cerebral cortex. The expression of therat counterpart in the frontal cortex and hippocampus was shown tobe induced by elctroconvulsive treatment (ECT) as well as chronicantidepressant treatment, suggesting that this gene may be amolecular target for ECT and antidepressants. The protein is aubiquitin ligase that functions in the endoplasmicreticulum-associated degradation pathway. Alternative splicing ofthis gene results in multiple transcript variants. Read-throughtranscription also exists between this gene and the downstreamVPS24 (vacuolar protein sorting 24 homolog) gene. [provided byRefSeq].
Scheper, J., et al. Proteins 74(1):92-103(2009)Maruyama, Y., et al. Biochem. Biophys. Res. Commun. 374(4):737-741(2008)Yang, Y., et al. Meth. Enzymol. 398, 103-112 (2005) :Nishioka, G., et al. J Neural Transm 110(3):277-285(2003)Yamada, M., et al. Biochem. Biophys. Res. Commun. 278(1):150-157(2000)
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