|Other Names||Leptin, Obese protein, Obesity factor, LEP, OB, OBS|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.|
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This gene encodes a protein that is secreted by whiteadipocytes, and which plays a major role in the regulation of bodyweight. This protein, which acts through the leptin receptor,functions as part of a signaling pathway that can inhibit foodintake and/or regulate energy expenditure to maintain constancy ofthe adipose mass. This protein also has several endocrinefunctions, and is involved in the regulation of immune andinflammatory responses, hematopoiesis, angiogenesis and woundhealing. Mutations in this gene and/or its regulatory regions causesevere obesity, and morbid obesity with hypogonadism. This gene hasalso been linked to type 2 diabetes mellitus development. [providedby RefSeq].
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Qin, J., et al. J. Hum. Genet. 55(10):704-706(2010)Friedlander, Y., et al. Ann. Hum. Genet. 74(5):387-398(2010)Sarzynski, M.A., et al. Int J Obes (Lond) (2010) In press :Iciek, R., et al. Ginekol. Pol. 81(8):571-577(2010)
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