|Other Names||Copine-3, Copine III, CPNE3, CPN3, KIAA0636|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870).|
|Cellular Location||Nucleus. Cytoplasm. Cell membrane. Cell junction. Cell junction, focal adhesion. Note=Associates to the membrane in a calcium-dependent manner (PubMed:20010870) Translocates to the cell membrane and the nucleus in a calcium- or growth factor heregulin-dependent manner (PubMed:21087455, PubMed:20010870). Colocalizes with the tyrosine phosphorylated ERBB2 form at cell membrane and focal adhesions in a calcium- or growth factor heregulin-dependent manner (PubMed:20010870)|
|Tissue Location||Expressed in breast and weakly in prostate and ovarian tissues (PubMed:20010870). Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed (PubMed:11041869). Expressed in the brain. Expressed in neutrophil precursors from the bone marrow and peripheral blood (PubMed:12949241). Expressed in primary breast tumors and ovarian endometrioid adenocarcinoma (PubMed:20010870)|
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Provided below are standard protocols that you may find useful for product applications.
Calcium-dependent membrane-binding proteins may regulatemolecular events at the interface of the cell membrane andcytoplasm. This gene encodes a protein which contains two type IIC2 domains in the amino-terminus and an A domain-like sequence inthe carboxy-terminus. The A domain mediates interactions betweenintegrins and extracellular ligands.
Heinrich, C., et al. Oncogene 29(11):1598-1610(2010)Thomas, G., et al. Nat. Genet. 40(3):310-315(2008)Cowland, J.B., et al. J. Leukoc. Biol. 74(3):379-388(2003)Caudell, E.G., et al. Biochemistry 39(42):13034-13043(2000)Creutz, C.E., et al. J. Biol. Chem. 273(3):1393-1402(1998)
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