|Other Names||SH3 domain-binding protein 2, 3BP-2, SH3BP2, 3BP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.|
|Tissue Location||Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene has an N-terminalpleckstrin homology (PH) domain, an SH3-binding proline-richregion, and a C-terminal SH2 domain. The protein binds to the SH3domains of several proteins including the ABL1 and SYK proteintyrosine kinases , and functions as a cytoplasmic adaptor proteinto positively regulate transcriptional activity in T, naturalkiller (NK), and basophilic cells. Mutations in this gene result incherubism. Multiple transcript variants encoding different isoformshave been found for this gene.
Lietman, S.A., et al. J. Orthop. Res. 28(11):1425-1430(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Davila, S., et al. Genes Immun. 11(3):232-238(2010)Amaral, F.R., et al. J. Oral Pathol. Med. 39(3):269-274(2010)Shukla, U., et al. J. Biol. Chem. 284(49):33719-33728(2009)
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